Multi‐functional MBIT for peptide tandem mass spectrometry
نویسندگان
چکیده
منابع مشابه
Learning Peptide-Spectrum Alignment Models for Tandem Mass Spectrometry
We present a peptide-spectrum alignment strategy that employs a dynamic Bayesian network (DBN) for the identification of spectra produced by tandem mass spectrometry (MS/MS). Our method is fundamentally generative in that it models peptide fragmentation in MS/MS as a physical process. The model traverses an observed MS/MS spectrum and a peptide-based theoretical spectrum to calculate the best a...
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2007 I To my wife Bai Hong, mother and father You all deserve the pride! II Acknowledgements I would like to first thank my family, especially my parents and my wife, for their endless support every day, month and year during my pursuit of PhD. I would like to take this opportunity to thank Prof. Leong Hon Wai for his patience, constant guidance and countless insightful suggestions throughout m...
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Bioinformatics is a hybrid science at the interface between biology and computer science. For nearly two centuries, data acquisition in the wet lab and in the field has limited the pace of progress in biology. With the advent of high-throughput technologies such as genome sequencing, data analysis has become an additional bottleneck, and simultaneously a rich source of computational and statist...
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The high-throughput nature of proteomics mass spectrometry is enabled by a productive combination of data acquisition protocols and the computational tools used to interpret the resulting spectra. One of the key components in mainstream protocols is the generation of tandem mass (MS/MS) spectra by peptide fragmentation using collision induced dissociation, the approach currently used in the lar...
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Picomole samples of the linear peptide gramicidin D and cyclic peptide gramicidin S are shown to be impure by the laser-desorption formation of multiple groups of molecular adduct peaks by using Fourier-transform mass spectrometry. Selective excitation of the molecular peaks of the major sample component followed by collisionally activated dissociation provides complete sequence information for...
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ژورنال
عنوان ژورنال: Mass Spectrometry Reviews
سال: 2014
ISSN: 0277-7037,1098-2787
DOI: 10.1002/mas.21435